Table 1.
Patient and clinical characteristics of children with RMS, based on all patients (n = 210) and according to time periods
| 1984–2010 (n = 211) | 1984–1989 (n = 49) | 1990–1999 (n = 68) | 2000–2010 (n = 94) | p Value* | |
|---|---|---|---|---|---|
| Sex (%) | |||||
| Male | 113 (54) | 27 (55) | 37 (55) | 49 (52) | NS |
| Female | 97 (46) | 22 (45) | 30 (45) | 45 (48) | |
| Age (years) (%) | |||||
| <1 | 24 (11) | 8 (16) | 9 (13) | 7 (7) | NS |
| 1–9 | 152 (72) | 31 (63) | 50 (75) | 71 (76) | |
| 10–14 | 34 (16) | 10 (20) | 8 (12) | 16 (17) | |
| Subtype (%) | |||||
| Embronal RMS | 151 (81) | 33 (87) | 48 (81) | 70 (78) | NS/0.015 |
| Alveolar RMS | 36 (19) | 5 (13) | 11 (19) | 20 (22) | |
| Others1 | 23 | 11 | 8 | 4 | |
| Tumour size (%) | |||||
| ≤5 cm | 92 (58) | 9 (50) | 31 (53) | 52 (62) | NS/<0.001 |
| >5 cm | 68 (43) | 9 (50) | 27 (47) | 32 (38) | |
| Missing | 50 | 31 | 9 | 10 | |
| Primary site (%) | |||||
| HNPM2 | 54 (26) | 12 (25) | 14 (21) | 28 (30) | 0.002/0.006 |
| HN‐nonPM3 | 26 (13) | 6 (13) | 13 (20) | 7 (8) | |
| UG‐nonBP4 | 26 (13) | 7 (15) | 9 (14) | 10 (11) | |
| EXT5 | 26 (13) | 2 (4) | 10 (15) | 14 (15) | |
| UG‐BP6 | 25 (12) | 2 (4) | 10 (15) | 13 (14) | |
| ORB7 | 15 (7) | 2 (4) | 2 (3) | 11 (12) | |
| OTH8 | 35 (17) | 17 (35) | 8 (12) | 10 (11) | |
| Missing | 3 | 1 | 1 | 1 | |
| Favourable9 | 69 (33) | 15 (31) | 25 (38) | 29 (31) | NS/NS |
| Unfavourable10 | 138 (67) | 33 (69) | 41 (62) | 64 (69) | |
| Missing | 3 | 1 | 1 | 1 | |
| Metastatic status (%) | |||||
| Localised RMS | 161 (81) | 40 (91) | 56 (88) | 65 (72) | 0.010/0.021 |
| Metastatic RMS | 37 (19) | 4 (9) | 8 (13) | 25 (28) | |
| Missing | 12 | 5 | 3 | 4 | |
*p Value determined by chi‐square test (missing information excluded/included). 1Includes patients diagnosed with RMS without further specified subtype or missing information about subtype in the registry. 2Head and neck (parameningeal), 3Head and neck (nonparameningeal), 4Genitourinary (not bladder or prostate), 5Extremities, 6Genitourinary (bladder or prostate), 7Orbit, 8Other sites, 9Orbit, genitourinary (not bladder or prostate) and head and neck (nonparameningeal), 10Extremities, genitourinary (bladder or prostate), head and neck (parameningeal), and other sites.