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. 2016 Jan 25;68(2):521–531. doi: 10.1002/art.39414

Figure 2.

Figure 2

Prevention of cartilage degradation following selective inhibition of membrane type 1 matrix metalloproteinase in mice with collagen‐induced arthritis (CIA). A, Histologic analysis of a joint from a normal mouse and arthritic joints from mice with CIA treated for 10 days with IgG control or with 20 or 40 mg/kg of DX‐2400. Images at the top are representative images of Safranin O–stained sections of the tarsometatarsal joints. Images at the bottom are higher‐magnification views of the boxed areas in the images at the top. Bar = 200 μm. The mean cartilage thickness (bottom left) and bone erosion scores (bottom right) in the tarsometatarsal joints of mice from the same treatment groups are also shown (n = 22–23 mice per group). For the mean cartilage thickness, each symbol represents an individual mouse; horizontal lines with bars show the mean ± SEM. For the bone erosion scores, values are the mean ± SEM. ∗∗∗ = P < 0.001. B, Serum levels of cartilage oligomeric matrix protein (COMP) in normal mice and mice with CIA treated for 10 days with IgG control or with 20 or 40 mg/kg of DX‐2400 (n = 22–23 mice per group). Each symbol represents an individual mouse; horizontal lines with bars show the mean ± SEM. ∗ = P < 0.05.