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. 2016 Jan 25;68(2):521–531. doi: 10.1002/art.39414

Figure 3.

Figure 3

Synergistic enhancement of the efficacy of anti–tumor necrosis factor (anti‐TNF) treatment following selective inhibition of membrane type 1 matrix metalloproteinase in mice with collagen‐induced arthritis (CIA). Mice with CIA were treated with IgG control, 20 mg/kg of DX‐2400, 2 or 8 mg/kg of TNFR‐Fc fusion protein, or 20 mg/kg of DX‐2400 plus 2 mg/kg TNFR‐Fc for 10 days from the onset of arthritis (n = 18–23 mice per group). Clinical scores (left) and paw swelling (first affected paw) (right) are shown at the top. Arrows indicate injection times. Values are the mean ± SEM. The number of affected paws 10 days after the onset of arthritis is shown at the bottom. Each symbol represents an individual mouse; horizontal lines with bars show the mean ± SEM. ∗ = P < 0.05; ∗∗ = P < 0.01; ∗∗∗ = P < 0.001 for the indicated comparisons or versus IgG control.