Table 2.
Metabolic changes at the end of 8-week treatment.
| Control (n = 16) | KME-W (n = 16) | KME-E (n = 16) | Normal-control (n = 16) | |
|---|---|---|---|---|
| Body weight (g) | 337 ± 31b | 342 ± 32b | 358 ± 34b | 407 ± 37a |
| Epididymal fat pads (g) | 4.2 ± 0.6b | 3.3 ± 0.6c | 3.6 ± 0.5c | 5.9 ± 0.8a |
| Relative epididymal fat pad (g/kg bw) | 12.4 ± 1.7b | 9.6 ± 1.4c | 10.1 ± 1.6c | 14.5 ± 1.9a |
| Caloric intakes (kcal/day) | 128 ± 16a | 118 ± 14a | 117 ± 15a | 101 ± 14b |
| Energy expenditure (kcal/kg0.75/day) | 92.1 ± 12.1 | 97.9 ± 12.1 | 92.7 ± 11.6 | 94.3 ± 11.6 |
| Carbohydrate oxidation (mg/kg0.75/min) | 3.9 ± 0.5a | 3.7 ± 0.5ab | 3.4 ± 0.4b | 4.2 ± 0.5a |
| Fat oxidation (mg/kg0.75/min) | 5.9 ± 0.8b | 6.8 ± 0.8a | 6.5 ± 0.7ab | 5.8 ± 0.7b |
| Overnight fasted serum leptin levels (ng/mL) | 5.5 ± 0.8b | 4.4 ± 0.7c | 4.2 ± 0.8c | 6.5 ± 0.9a |
| Overnight fasted serum glucose (mmol/L) | 8.0 ± 1.0a | 7.5 ± 0.9a | 6.6 ± 0.8b | 5.4 ± 0.6c |
| Overnight fasted serum insulin (ng/mL) | 0.82 ± 0.14b | 0.88 ± 0.15b | 1.07 ± 0.19a | 1.14 ± 0.20a |
| Serum AST (IU/L) | 130 ± 13.0a | 112 ± 12b | 118 ± 13b | 125 ± 13a |
| Serum ALT (IU/L) | 45 ± 4.8a | 36.4 ± 4.2b | 38.4 ± 4.4b | 44.2 ± 4.6a |
Values are mean ± SD. Diabetic Px rats were fed with high-fat diets supplementing (1) 0.6% water extract of Korean mistletoe (KMW-W), (2) 0.6% of 70% ethanol extract (KME-E), or (3) 0.6% dextrose (Control). Sham-operated rats were provided with a high-fat diet containing 0.6% dextrose as a normal-control.
a,b,cValues in the same row with different superscripts were significantly different in Tukey test at P < 0.05.