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. 2016 Feb 3;35:25. doi: 10.1186/s13046-016-0300-8

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© Zhao et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Downregulation of miR-302 expressions in MCF-7/ADR cells. a Cells were treated with various concentrations of ADR, PAC or VP-16. Survived cells were measured by MTS assay. MTS assay shows that MCF-7/ADR cells are much more resistant to ADR, PAC and VP-16 than MCF-7 cells (b) Left: Western blotting analysis showing the protein expression of MRP, P-gp, LRP, and BCRP in MCF-7 and MCF-7/ADR cells. GAPDH was used as an internal loading control. Right: Densitometric analysis for the detected protein expression. c Sequence alignment of human miR-302 family miRNAs. d qRT-PCR indicates a significant down-regulation of miR-302 in MCF-7/ADR cells compared with MCF-7 cells. All graphs show means ± S.D. of three independent experiments