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. 2016 Feb 3;35:25. doi: 10.1186/s13046-016-0300-8

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© Zhao et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — miR-302 modulated the resistance of human breast cancer cells to chemotherapeutic drugs. a qRT-PCR showing the relative expression of miR-302a/b/c/d in untreated MCF-7 and MCF-7/ADR cells (Blank), cells treated with miR-302a,b,c,d mimics (a final concentration of 20nM) or the four miRNAs mimic combination (miR-302S,the miRNAs mixed with miR-302a, miR-302b, miR-302c and miR-302d mimics by same concentration (4 × 5nM = 20nM) and negative controls (NC). b Following untransfection (Blank), transfection with either of the negative control RNA (NC) or miR-302 mimic, cells were treated with various concentrations of ADR, PAC and VP-16 for 48 h, respectively. The effect of the miR-302 mimic on the viability of MCF-7 cells and MCF-7/ADR in response to the three chemotherapeutic drugs was determined using the MTS assay. n = 3 (*P < 0.05 compared with the control group, ^# P < 0.05 compared with individual member)