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. 2016 Feb 3;35:25. doi: 10.1186/s13046-016-0300-8

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© Zhao et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — miR-302a,b,c and d directly targeted the 3′UTR of MEKK1 mRNA with cooperative effects. a Validation of the miR-302 target site in the 3′UTR of MEKK1 mRNA. The putative miR-302 targeted sequence in the MEKK1 mRNA. b RNAhybrid predicts one binding site of miR-302 in the MEKK1 3'-UTRs. The binding energy was calculated c & d Dual-luciferase assays showing repression of wild-type UTR MEKK1-3′UTR-FULL (c) or mutant UTR MEKK1-3′UTR-MUT (d) following transfection of miR-302 mimics or negative control mimic (NC). All graphs show means ± S.D. of three independent experiments. (* P < 0.05 vs. NC;^# P < 0.05 vs. Single)