Table 3.
ATTReuNET-compiled type and frequency of TTR-FAP biopsies performed across Europe
| Country | ||||||||||
| Portugal | Cyprus | Sweden | Bulgaria | Germany | The Netherlands | Turkey | France | Spain | Italy | |
| Estimated number of TTR-FAP cases declared, n | 2000 | 50 | 250 | 87 | 120 | 80 | 20–30 | 500 | 500 | 200 |
| Site of biopsy, % performed in each centrea | ||||||||||
| Abdominal fat aspiration | 3 | – | 100 | – | 40–60 | 100 | 10–15 | – | 50 | 85 |
| Sural nerve | 2 | – | – | – | 15–20 | – | 75 | 40 | 15 | – |
| Rectal | – | 100 | – | 80 | 25–40 | 25 | – | – | 30 | – |
| Labial salivary gland | 95 | – | – | 6 | – | – | 10–15 | 100 | 5 | 5 |
| Gastric | – | – | 20–80b | – | – | – | – | 5 | – | – |
| Heart | – | – | 5 | 2 | – | 10 | – | < 5 | – | 10 |
| Others | – | – | 0–5c | 12 | – | – | – | – | – | – |
| Types of biopsies performed, n | 3 | 1 | 3 | 5 | 3 | 3 | 3 | 4 | 4 | 3 |
ATTReuNET, European Network for TTR-FAP; TTR-FAP, transthyretin familial amyloid polyneuropathy.
aWhere total numbers exceed 100%, more than one biopsy was performed.
bAs part of routine evaluation of gastric function.
cSkin, n = 6; renal, n = 6.