Fig. 1.

Association between CSF and plasma NFL and concentrations of biomarkers in 8 subject groups. Panels a–b and d–f, plot concentrations of different markers for the 8 subject groups, HIV-negative controls (HIV-neg); primary HIV infection (PHI); untreated neuroasymptomatic subjects in different CD4 cell strata (Asympt); HIV-associated dementia (HAD); and subjects on suppressive antiretroviral treatment (ART). Boxes depict median and IQR, whiskers show 10–90 percentiles and ‘+’ designates the means. Dotted horizontal lines in panels d–e show the limit of detection for HIV RNA (40 copies/mL), and in panel f the upper limit of normal for CSF neopterin (5.8 nmol/L). Panel c plots the correlation between log CSF and log plasma NFL.