Fig. 3.

Cells performing OXPHOS activate an antioxidant response in vitro and in vivo in primary leukemic cells. A) Tumor cells from 4 hematological cancer patients (2 MM, 1 B-CLL and 1 T cell lymphoma) were treated with various concentrations of DCA for 24 h and mRNA was analyzed by qPCR. B) NSG mice were engrafted with primary human AML cells. At day 80 post-graft, they were treated with DCA (n = 4) or left untreated (n = 4). At day 140 mRNA from AML tumor cell from bone marrow or spleen was isolated and the expression of different proteins was quantified by qPCR. The data represent means ± SD; *p < 0.05, **p < 0.01, ***p < 0.001 Student's t-test compared to non treated cells or mice.