Table 1.
Adoptive transfer of bulk splenocytes and serum from vaccinated animals to naïve animals.
| Group | Transfer group (donor animals) | Number of cells | Cell type | Serum (μl) | Number of animalsa | Percent survival | Challenge material | Challenge dose level |
|---|---|---|---|---|---|---|---|---|
| 1 | PolyICLC + VLP | 5e6 | Splenocytes | 200 | 10a | 90 | Ma-EBOV | 1000 pfu |
| 2 | 20e6 | Splenocytes | 200 | 24a | 83 | |||
| 3 | 20e6 | Splenocytes | n/a | 10a | 0 | |||
| 4 | n/a | n/a | 200 | 5 | 0 | |||
| 5 | VLP | 5e6 | Splenocytes | 200 | 5 | 0 | ||
| 6 | 20e6 | Splenocytes | 200 | 5 | 0 | |||
| 7 | 20e6 | Splenocytes | 500 | 3 | 0 | |||
| 8 | n/a | n/a | n/a | n/a | 60a | 0 |
a
Pooled from multiple iterations with n = 4 to 10 per iteration. Fisher's exact test with Bonferroni correction, pairwise comparisons were used to evaluate Group 1 vs. 2 (p = 0.3819), 1 vs. 4 (p = 0.006), 1 vs. 5 (p = 0.006), 2 vs. 3 (p = 0.0005), and 2 vs. 6 (0.0044).