Table 5.
Predictive value of clinical and pathological characteristics to Mandard response (univariate analysis).
| Variables | n | Bad responders % (Mandard TRG 3–5) | Odds ratio | p |
|---|---|---|---|---|
| Distance from anal verge | ||||
| ≤6 cm | 86 | 58.0 | 1.00 | 0.017 |
| >6 cm | 81 | 39.5 | 2.11 (1.14–3.92) | |
| Mitosis number in resected specimen | ||||
| ≤9.5 | 73 | 32.9 | 1.00 | <0.001 |
| ≥9.6 | 68 | 77.9 | 7.21 (3.40–15.32) | |
| Necrosis grade in resected specimen | ||||
| Scarce | 27 | 77.8 | 10.36 (3.76–28.57) | <0.001 |
| Moderate | 38 | 92.1 | 34.53 (9.76–122.41) | <0.001 |
| Marked | 99 | 25.3 | 1.00 | <0.001 |
| CRM distance | ||||
| ≥2 mm | 159 | 45.9 | 1.00 | 0.003 |
| <2 and >1 mm | 8 | 100 | 2.18 (1.84–2.58) | |
| ypT stage | ||||
| 0-1 | 38 | 7.9 | 1.00 | <0.001 |
| 2–4 | 129 | 60.5 | 17.84 (5.21–61.09) | |
| ypN stage | ||||
| 0 | 110 | 32.7 | 1.00 | |
| 1-2 | 57 | 78.9 | 7.71 (3.64–16.34) | <0.001 |
| Pathological stage | ||||
| 0-I | 58 | 15.5 | 1.00 | <0.001 |
| II | 58 | 55.2 | 6.70 (2.78–16.14) | <0.001 |
| III | 51 | 78.4 | 19.80 (7.47–52.48) | <0.001 |
| T downstaging | ||||
| Yes | 67 | 23.9 | 1.00 | <0.001 |
| No | 100 | 65.0 | 5.92 | |
| Pathological TNM downstaging | ||||
| Yes | 96 | 34.4 | 1.00 | <0.001 |
| No | 70 | 67.1 | 3.90 | |
| Reduction of mitosis number | ||||
| Yes | 83 | 41.0 | 1.00 | <0.001 |
| No | 52 | 73.1 | 3.91 (1.84–8.30) | |
| Differentiation grade in resected specimen | ||||
| 0 + 1 | 52 | 15.4 | 1.00 | <0.001 |
| 2 + 3 | 115 | 63.5 | 9.56 |