Skip to main content
. 2016 Feb 3;11(2):e0148463. doi: 10.1371/journal.pone.0148463

Table 3. Bootstrapped multivariate regression analysis for fatigue (FA), nausea and vomiting (NV), appetite loss (AP) and pain (PA).

FA NV AP PA
Coeff 95% CI p Coeff 95% CI p Coeff 95% CI p Coeff 95% CI p
Intercept 19.75 (5.80; 33.70) 0.006 7.48 (-1.83; 16.79) 0.12 18.59 (0.69; 36.50) 0.04 26.21 (10.17; 42.24) 0.001
Baseline 0.65 (-0.46; -0.05) <0.001 0.47 (0.36; 0.58) <0.001 0.56 (0.49; 0.63) <0.001 0.63 (0.56; 0.60) <0.001
Age -0.25 (-046; -0.05) 0.02 -0.17 (-0.32; -0.02) 0.03 -0.25 (-0.50; 0.001) 0.05 -0.33 (-0.55; -0.10) 0.004
Women 1.40 (-2.03; 4.83) 0.42 1.61 (-0.82; 4.04) 0.19 1.92 (-2.57; 6.42) 0.40 1.79 (-2.15; 5.74) 0.37
Cancer 5.88 (0.43; 11.35) 0.04 3.35 (-0.43; 7.13) 0.08 10.06 (2.95; 17.17) 0.006 -0.89 (-7.71; 5.93) 0.80
Duration of symptom (weeks) 0.04 (-0.06; 0.14) 0.46 0.001 (-0.06; 0.06) 0.99 0.11 (-0.02; 0.25) 0.10 -0.01 (-0.12; 0.11) 0.94
Previous cancer in patient -0.71 (-8.05; 6.62) 0.85 -0.59 (-4.91; 3.73) 0.78 5.52 (-4.21; 15.25) 0.27 -4.83 (-12.79; 3.12) 0.23
Co-morbidity
    0 1 1 1 1
    1 4.11 (-0.24; 8.46) 0.06 3.27 (0.37; 6.16) 0.03 3.39 (-2.36; 9.14) 0.25 9.23 (3.91; 14.55) 0.001
    ≥2 8.97 (3.66; 14.28) 0.001 4.64 (1.38; 7.89) 0.005 4.53 (-2.33; 11.39) 0.20 8.34 (2.51; 14.18) 0.005
Marital status
    Married/Co-inhabitant 1 1 1 1
    Separated/divorced 0.49 (-5.58; 6.57) 0.87 4.18 (-1.25; 9.61) 0.13 2.40 (-5.79; 10.60) 0.57 3.05 (-3.55; 9.65) 0.37
    Widow/widower 0.77 (-5.98; 7.52) 0.82 -0.95 (-5.63; 3.74) 0.69 1.76 (-5.52; 9.03) 0.64 -2.19 (-9.59; 5.21) 0.56
    Unmarried/single -6.60 (-12.71; -0.49) 0.03 -1.35 (-5.28; 2.57) 0.50 -3.78 (-12.85; 5.29) 0.42 -4.81 (-12.27; 2.65) 0.21
Education
    Basic school/high school 1 1 1 1
    Vocational training (10–12 years) -0.36 (-5.08; 4.36) 0.88 -1.68 (-4.87; 1.49) 0.30 -0.38 (-6.84; 6.09) 0.91 1.72 (-4.06; 7.49) 0.56
    Medium academic/trade (<15 years) -2.84 (-7.77; 2.09) 0.26 -0.84 (-3.94; 2.27) 0.60 -3.64 (-9.88; 2.60) 0.25 1.46 (-4.51; 7.42) 0.63
    Academic/university level (>15 years) -3.15 (-9.01; 2.69) 0.29 0.18 (-3.74; 4.10) 0.92 -4.22 (-11.85; 3.41) 0.28 -1.44 (-8.62; 5.75) 0.70
Occupation
    Employed 1 1 1 1
    Unemployed 9.91 (0.84; 18.98) 0.03 2.90 (-6.31; 12.11) 0.54 1.82 (-13.73; 17.37) 0.82 6.20 (-4.55; 16.94) 0.26
    Retired/disability/early retirement 1.56 (-3.60; 6.73) 0.55 3.78 (0.05; 7.51) 0.05 4.94 (-1.31; 11.19) 0.12 1.65 (-4.59; 7.88) 0.61
Follow-up after diagnosis -2.02 (-6.14; 2.11) 0.34 -1.38 (-4.52; 4.04) 0.19 -3.90 (-9.81; 2.02) 0.20 -4.54 (-9.74; 0.67) 0.09