Table 2. Placental GR isoform expression in relation to gestational age at delivery, fetal sex and betamethasone exposure.
| Control Preterm | Control Term | Steroid Preterm | Steroid Term | P Value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Female | Male | Female | Male | Female | Male | Female | Male | ||||
| n | 6 | 7 | 6 | 8 | 6 | 8 | 8 | 7 | |||
| GRγ | Cytoplasm | 0.7 | 0.07 | 4.2 | 2.3 | 5.23 | 5.67 | 0.3 | 0.8 | 0.004 | |
| Range | 0.5–0.8 | 0.4–2.7 | 1.9–4.9 | 1.5–4.1 | 3.4–7.9 | 0.9–13.0 | 0.2–1.4 | 0.4–1.2 | |||
| Nucleus | 0.5 | 1.2 | 0.8 | 1.4 | 4.29 | 2.3 | 0.03 | 0.6 | |||
| Range | 0.2–1.2 | 0.5–2.2 | 0–1.8 | 0–2.8 | 1.4–8.0 | 0.9–7.4 | 0.3–1.5 | 0–1.6 | |||
| GRα A | Cytoplasm | 1.4 | 0.9 | 0 | 11.1 | 16.6 | 14.8 | 1.8 | 6.1 | 0.0001 | |
| Range | 0.7–2.0 | 0.7–1.4 | 0–1.7 | 2.9–17.5 | 10.9–20.9 | 11.1–30.4 | 1.3–5.6 | 1.1–6.8 | |||
| Nucleus | 1.6 | 0.7 | 0.5 | 7.7 | 4.82 | 10.1 | 1.3 | 2.4 | 0.001 | ||
| Range | 0.8–2.4 | 0–0.8 | 0–1.2 | 2.3–10.6 | 0.71–12.5 | 4.8–19.6 | 0.9–2.1 | 2.1–5.1 | |||
| GRβ | Cytoplasm | 0.8 | 0.4 | 0 | 0 | 2.55 | 4.2 | 0.5 | 2.6 | 0.01 | |
| Range | 0.6–1.2 | 0–0.6 | 0 | 0–3.9 | 0.3–3.57 | 2.9–5.9 | 0.5–1.5 | 0.3–6.0 | |||
| Nucleus | 0.5 | 0 | 0 | 0 | 2.32 | 3.5 | 3 | 1.8 | 0.0001 | ||
| Range | 0–2.2 | 0 | 0 | 0 | 1.7–2.6 | 2.4–4.7 | 1.42–3.7 | 1.5–3.5 | |||
| GR P | Cytoplasm | 1.5 | 0.7 | 2.9 | 3.5 | 8.44 | 9.7 | 1.4 | 2.3 | ||
| Range | 0.6–2.3 | 1.3–2.9 | 1.6–4.9 | 0–11.8 | 5–11.2 | 0–22.8 | 1.2–2.9 | 0.7–3.9 | |||
| Nucleus | 1.4 | 0 | 0.8 | 3.1 | 0 | 10.4 | 1.3 | 1.4 | |||
| Range | 0–2.6 | 0–1.1 | 0–16 | 0–11.2 | 0–0.85 | 1.0–16.6 | 1.0–2.7 | 0–2.0 | |||
| GR A | Cytoplasm | 2.8 | 2.9 | 6.1 | 22.6 | 17.4 | 18.9 | 2.8 | 6.1 | 0.004 | |
| Range | 2.6–3.2 | 2.6–4.2 | 4.3–7.2 | 10.5–46.2 | 10.4–22.7 | 12.9–27.0 | 2.4–4.9 | 1.1–10.4 | |||
| Nucleus | 2.3 | 1.5 | 3.9 | 13.03 | 10.1 | 15.5 | 2.3 | 2.8 | 0.0001 | ||
| Range | 1.6–3.0 | 0–1.8 | 1.5–13.8 | 9.6–15.7 | 5.9–11.4 | 8.4–23.3 | 1.9–3.7 | 2.1–5.6 | |||
| GRα D1 | Cytoplasm | 0.4 | 0 | 3.1 | 0 | 5.44 | 10.9 | 0.9 | 2.8 | 0.02 | |
| Range | 0–1.1 | 0–0.4 | 3.1–3.4 | 0–4.3 | 0–11.6 | 4.8–18.8 | 0.4–2.2 | 0.6–3.4 | |||
| Nucleus | 0.5 | 0 | 8.4 | 0 | 0 | 8.2 | 0.7 | 1.7 | 0.005 | ||
| Range | 0–2.6 | 0 | 1.6–20.8 | 0–2.2 | 0–4.2 | 4.7–12.7 | 0.6–0.9 | 0–2.6 | |||
| GRα D2 | Cytoplasm | 2.1 | 0.9 | 8 | 6 | 4.1 | 16.3 | 2 | 5.9 | 0.01 | |
| Range | 0.7–3.7 | 0.4–5.9 | 3.6–13.6 | 1.9–6.5 | 3.3–7.6 | 7.39–23.4 | 1.8–2.4 | 1.2–8.2 | |||
| Nucleus | 3.8 | 1.5 | 4.7 | 5.7 | 7.23 | 11.4 | 2.4 | 4.6 | 0.02 | ||
| Range | 1–5.1 | 0.6–2.7 | 3.1–24.8 | 2.8–9.4 | 0.9–8.8 | 7.0–17.3 | 1.7–3.7 | 1.1–5.1 | |||
| GRα D3 | Cytoplasm | 2.1 | 1.1 | 0 | 15.9 | 9.82 | 8.1 | 2 | 3.7 | 0.0001 | |
| Range | 1.7–3.0 | 0.8–1.6 | 0–2.5 | 6.8–22.7 | 6.8–10.5 | 4.6–10.8 | 1–4.3 | 2–5.5 | |||
| Nucleus | 1.7 | 0 | 0 | 12.7 | 3.4 | 10.6 | 1.5 | 2.5 | 0.0001 | ||
| Range | 1.6–2.1 | 0–1.3 | 0 | 3.6–21.7 | 0.63–7.23 | 4.6–15.1 | 1.0–3.7 | 2–4.3 | |||
| 45 kDa | Cytoplasm | 1.2 | 0.9 | 0 | 4 | 3.85 | 7 | 1.3 | 3.2 | ||
| Range | 0–2.1 | 0–1.0 | 0 | 0–12.1 | 0–11.9 | 0–14.2 | 1.1–4.8 | 2.2–4.7 | |||
| Nucleus | 1.4 | 0 | 0 | 4.8 | 0 | 0 | 1.4 | 2.3 | |||
| Range | 0–2.3 | 0–0.8 | 0 | 0–6.9 | 0–5.6 | 0–11.6 | 1.2–1.7 | 1.6–5.3 | |||
| 38 kDa | Cytoplasm | 1.6 | 1.9 | 5.5 | 0 | 6.96 | 13.8 | 1.9 | 4.5 | 0.0001 | |
| Range | 1.4–2.3 | 1.6–6.6 | 3.9–8.8 | 0 | 6.1–11.9 | 11–23.7 | 1.2–3.0 | 0.7–5.7 | |||
| Nucleus | 2.9 | 1.5 | 11.9 | 0 | 9.73 | 12.8 | 2.2 | 2.6 | 0.0001 | ||
| Range | 2.4–3.3 | 1.3–2.1 | 3.8–23.6 | 0 | 5.1–18.9 | 6.5–20.6 | 1.9–5.9 | 2.5–5.9 | |||
Data is expressed as median and inter-quartile range.