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. 2016 Feb 3;11(2):e0148229. doi: 10.1371/journal.pone.0148229

Fig 1. E. chaffeensis-specific IgG response following Ech_0660 vaccination and secondary challenge with wild-type E. chaffeensis.

Fig 1

Total E. chaffeensis-specific IgG was measured in the plasma at multiple time points by ELISA in dogs vaccinated with the Ech_0660 mutant and challenged with wild-type E. chaffeensis via needle inoculation (group 1), or vaccinated with Ech_0660 and challenged with wild-type E. chaffeensis via tick-transmission (group 2). Unvaccinated control dogs were infected with wild-type E. chaffeensis or the non-attenuated Ech_0480 mutant via tick-transmission (group 3). Each line is representative of a single animal.