Table 4.

Multivariable Cox regression analysis of the association of margin width and recurrence in 2708^* women with DCIS treated with breast-conserving surgery, controlling for other factors

Variable		N	Events	HR	P
Age	Per year			0.978	<0.0001
Family history	No	1662	187	1	0.03
	Yes	1046	138	1.28
Presentation	Radiologic	2394	264	1	0.03
	Clinical	314	61	1.38
Number of excisions	1	1300	138	1	0.006
	2	1204	155	1.27
	≥3	204	32	1.96
Radiation	No	1225	201	1	<0.0001
	Yes	1483	124	0.44
Endocrine therapy	No	2110	285	1	<0.0001
	Yes	598	40	0.48
Year of surgery	1978–2000	826	188	1.47	0.002
	2001–2010	1882	137	1
Margin width	Positive	98	16	1	0.0003
	Close (≤2mm)	435	69	0.78
	>2–10mm	861	97	0.70
	>10mm	1314	143	0.44

^*In entire population of 2996, 288 cases had at least one missing data point, resulting in population for multivariable analysis of 2708.

HR, hazard ratio