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. 2016 Feb;15(2):542–557. doi: 10.1074/mcp.M115.051649

Table I. Association of signaling endosome components with human pathologies. Disease enrichment analysis was performed with Metacore using a hypergeometric test. The ratios between endosomal protein-coding genes and independent genes indicate the possible association of any given gene with neurological diseases. Selected genesets are listed in order of their statistical significance after Benjamini-Hochberg correction. p values < 0.05 are significant. Neurological diseases associated with axonal transport deficits are highlighted in bold. Neurological infections are marked with asterisks. Adj.p.value: adjusted p value.

Disease name adj.p.val Ratio
Central nervous system Diseases 1.89E-47 459/3069
Brain diseases 6.73E-46 435/2880
Schizophrenia 6.25E-43 203/914
Schizophrenia and disorders with psychotic features 9.56E-43 203/918
Neurodegenerative diseases 2.74E-39 336/2104
Mental disorders 3.50E-39 281/1614
Nervous system diseases 3.50E-39 665/5522
Psychiatry and psychology 8.79E-36 307/1919
Dementia 9.48E-32 255/1536
Tauopathies 6.13E-29 206/1166
Alzheimer's disease 2.04E-27 201/1153
Virus diseases* 1.68E-17 215/1531
TDP-43 proteinopathies 2.55E-17 54/180
Amyotrophic lateral sclerosis 9.00E-17 53/179
Heredodegenerative disorders, nervous system 1.19E-16 163/1064
Glioblastoma 7.15E-16 311/2579
Astrocytoma 9.92E-16 315/2628
Epilepsy 1.09E-15 90/455
Basal ganglia diseases 5.70E-15 129/799
Movement disorders 3.01E-14 135/871
Neuromuscular diseases 1.31E-13 176/1278
Spinal cord diseases 2.14E-13 72/352
Neurologic manifestations 2.38E-13 204/1566
Motor neuron disease 2.76E-13 59/257
Tay-Sachs disease 8.24E-13 12/12
Dyskinesias 8.98E-13 117/745
Brain diseases, metabolic 1.71E-12 62/290
Bacterial infections and mycoses* 1.76E-12 175/1307
Glioma 2.44E-12 534/5313
RNA virus infections* 4.27E-12 148/1055
Brain diseases, metabolic, inborn 9.98E-12 59/279
Neoplasms, neuroepithelial 1.00E-11 554/5596
Infection* 7.58E-11 157/1185
Down syndrome 1.94E-10 42/173
Huntington's disease 4.97E-09 75/461
Lysosomal storage diseases, Nervous system 5.14E-09 23/67
Parkinsonian disorders 2.45E-05 58/405
Frontotemporal lobar Degeneration 2.24E-04 18/80
Frontotemporal dementia 2.24E-04 18/80