Table 1. Micro CT analysis of femur bone structure changes in control, Fgfr1PT-cKO, and Fgfr1DT-cKO mice.
Femur | Control | Fgfr1PT-cKO | Control | Fgfr1DT-cKO |
---|---|---|---|---|
Trabecular Bone Volume (mm3) | 0.328 ± 0.019 | 0.1863 ± 0.093* | 0.273 ± 0.145 | 0.235 ± 0.056 |
Trabecular Bone Fraction (BV/TV) | 0.177 ± 0.017 | 0.101 ± 0.052* | 0.156 ± 0.075 | 0.131 ± 0.033 |
Trabecular Number (1/mm) | 3.813 ± 0.156 | 3.428 ± 0.543 | 4.302 ± 0.797 | 4.394 ± 0.567 |
Trabecular Thickness (mm) | 0.049 ± 0.004 | 0.043 ± 0.01 | 0.050 ± 0.006 | 0.043 ± 0.002* |
Trabecular Material BMD (mgHA/mm3) | 913.1 ± 21.3 | 896.1 ± 28.2 | 896.6 ± 19.2 | 859.7 ± 8.9** |
Cortical Thickness (mm) | 0.204 ± 0.011 | 0.203 ± 0.006 | 0.196 ± 0.012 | 0.179 ± 0.013* |
Data were presented as mean ± S.D. from mice (n = 5) of each genotype. One-tail unpaired t test
*P<0.05,
**P<0.01 vs control.