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. 2016 Jan 26;5:e09394. doi: 10.7554/eLife.09394

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© 2015, Ogawa et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 4. — (A, B) Th 17 cells (pink in A) and IL-6-producing cells (yellow in left panel of Figure 4B, arrows) were observed in the lacrimal gland of mismatched BMSC transplanted mice 8 weeks after transplantation. Yellow cells in (B) are due to co-localization of IL-6 (red) and donor BMSCs (GFP), resulting in yellow. Mismatched HSC transplanted mice did not show co-localization of donor cells (green) with IL-6 nor IL-17-producing cells. Representative images from two replicate experiments (n = 3 per group). Scale bar, 20 μm. (C) CD4⁺IL-17⁺ cells comprised more than 50% of splenic cells from B10.D2 BMSC + RAG2KO HSCs transplanted BALB/c recipients (left), while the ratio was low in spleens from B10.D2 BMSC + BALB/c HSC transplanted RAG2KO recipients (right). BMSC, bone marrow stromal/stem cells; HSC, hematopoietic stem cells.

DOI: http://dx.doi.org/10.7554/eLife.09394.018

Figure 4—figure supplement 1. — (A, B) Th 17 cells (pink in A) and IL-6-producing cells (yellow in left panel of Figure 4B, arrows) were observed in the lacrimal gland of mismatched BMSC transplanted mice 8 weeks after transplantation. Yellow cells in (B) are due to co-localization of IL-6 (red) and donor BMSCs (GFP), resulting in yellow. Mismatched HSC transplanted mice did not show co-localization of donor cells (green) with IL-6 nor IL-17-producing cells. Representative images from two replicate experiments (n = 3 per group). Scale bar, 20 μm. (C) CD4⁺IL-17⁺ cells comprised more than 50% of splenic cells from B10.D2 BMSC + RAG2KO HSCs transplanted BALB/c recipients (left), while the ratio was low in spleens from B10.D2 BMSC + BALB/c HSC transplanted RAG2KO recipients (right). BMSC, bone marrow stromal/stem cells; HSC, hematopoietic stem cells.

DOI: http://dx.doi.org/10.7554/eLife.09394.018