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. 2016 Jan 26;5:e09394. doi: 10.7554/eLife.09394

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© 2015, Ogawa et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 7. — (A) Serum IL-6 concentration increased after mismatched BMSC transplantation (red) compared to syngeneic control (blue). Duplicate experiments. Data are shown as mean ± SD, n = 2. (B) GFP⁺ donor BMSCs appear in peripheral blood mononuclear cells after mismatched BMSCs transplantation, and peaks at approximately 7 weeks. The percentage of BMSCs expressing MHC class II antigen increases following transplantation. (C) CD4⁺ CD25⁺ Foxp3⁺ Tregs were suppressed in the spleen after mismatched WBMT transplantation (right) compared to syngeneic control (left). (D) CD4⁺CD25⁺Foxp3⁺ Tregs were suppressed in both mismatched WBMT (yellow) and mismatched BMSC transplantation (red) compared to syngeneic WBMT (green) or syngeneic BMSCs transplantation (blue). Data are shown as mean ± SD, triplicate experiments, n = 3–5, **p<0.01. (E, F) The ratio of CD4⁺ IL-17⁺ T cells in the spleen was significantly higher following mismatched WBMT (yellow) or mismatched BMSC transplantation (red) compared to syngeneic control (green and blue). Data are shown as mean ± SD, triplicate experiments, n = 3–5, *p<0.05. BMSCs, bone marrow stromal/stem cells; SD, standard deviation.

DOI: http://dx.doi.org/10.7554/eLife.09394.029

Figure 7—source data 1. Serum IL-6 concentration after mismatched BMSC transplantation compared to syngeneic BMSC transplantation.
Data are from 2, 3, and 4 weeks after mismatched and syngeneic BMSC transplantation shown in (A).

DOI: http://dx.doi.org/10.7554/eLife.09394.030

elife-09394-fig7-data1.xls^{(46.5KB, xls)}

DOI: 10.7554/eLife.09394.030

Figure 7—source data 2. Serial changes of CD4⁺CD25⁺Foxp3⁺ Tregs in spleen cells.
Raw data and average values for statistical analysis use in (D) are shown.

DOI: http://dx.doi.org/10.7554/eLife.09394.031

elife-09394-fig7-data2.xls^{(53KB, xls)}

DOI: 10.7554/eLife.09394.031

Figure 7—source data 3. The ratio of CD4⁺ IL-17⁺ T cells in the spleen cells.
Raw data and average values for statistical analysis used in (E) are shown.

DOI: http://dx.doi.org/10.7554/eLife.09394.032

elife-09394-fig7-data3.xls^{(37.5KB, xls)}

DOI: 10.7554/eLife.09394.032