Figure 3. The Meselson effect.

An accumulation of mutations on separate haplotypes, the ‘Meselson Effect’, is illustrated using three regions on chromosome 10. For each region (1, 2 and 3) the two haplotypes are shown for a series of isolates with the accumulating mutations (filled boxes) indicated in red or blue for each haplotype. The sequences of accumulating mutations observed in the isolates ‘Lisa’ and ‘B4_F303P’ are shown. The number of mutations arising between each ancestral haplotype pair is indicated with two distinct lineages apparent at each locus, illustrating the independent evolution of each haplotype.

DOI: http://dx.doi.org/10.7554/eLife.11473.014