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. Author manuscript; available in PMC: 2016 Feb 3.
Published in final edited form as: Exp Hematol. 2011 Jan 21;39(4):446–456. doi: 10.1016/j.exphem.2011.01.004

Figure 3. Active transport of hydroxyurea is mediated by OATP1B3.

Figure 3

(A) Hydroxyurea uptake over time in OATP1B3 oocytes is significantly higher than uptake by controls (***P= .009). (B) OATP1B3 mediated accumulation of hydroxyurea at 4°C is reduced and remains linear over a time course compared to accumulation at room temperature that approaches saturation. (C) OATP1B3 mediated transport of hydroxyurea by is inhibited by co-incubation with naringin and other known OATP1B3 substrates. 1% DMSO solution was used as vehicle control. Each symbol or bar represents the mean ±SE of 3 independent experiments with at least 5 replicates per experimental point. **P<.01; *P<.05 compared to hydroxyurea alone