. Author manuscript; available in PMC: 2017 Jan 21.

Published in final edited form as: J Mater Chem B. 2015 Dec 1;4(3):394–408. doi: 10.1039/C5TB01613D

Table 4.

A549 cell cytotoxicity (EC₅₀) and phototoxicity indices for Ru complexes (N = 3) after 5 min light irradiation (λ>400 nm).

Complex	Formulation	EC₅₀(μM)		Phototoxicity Index, Pi^a
Complex	Formulation	Dark	Light	Phototoxicity Index, Pi^a
1	Free	>300	8.3 ± 1.2	> 36.1
1	CNA	>300	12.9 ± 1.1	>23.3
2	Free	9.7 ±1.3	3.9 ± 1.1	>2.5
2	CNA	9.6 ± 1.4	2.6 ±1.1	>3.7
3	Free	0.6 ± 1.1	0.1 ±1.0	>6
3	CNA	0.6 ±1.2	0.1 ±1.1	>6
cisplatin		2.5 ± 0.6	2.5 ±0.4	1

The Phototoxicity Index (PI) is a ratio of the dark and light A549 EC₅₀ values (see Figures S8 and S18 for cell viability curves).