Table 1.

Some deconvolution techniques.

Deconvolution Technique		Function
Model-Dependent	Wagner-Nelson (one-compartment model)	$F_t=\frac{C_t+K_e{\int }_0^t\mathit{Cdt}}{K_e{\int }_0^{\infty }\mathit{Cdt}}$
	Loo-Riegelman (two-compartment model)	$F_t=\frac{C_t+K_{10}{\int }_0^t\mathit{Cdt}+{(X_p)}_t/V_c}{K_{10}{\int }_0^{\infty }\mathit{Cdt}}$
	Mechanistic, Physiologically-based
Model-Independent	Numerical	$C(t)={\int }_0^t{C}_{\delta }(t-u)r_{\mathit{abs}}(u)du$

C_t: the plasma concentration at time t; K_e: the elimination rate constant; (X_p)/t: the amount of drug in the peripheral compartment as a function of time; V_c: the apparent volume of the central compartment; K₁₀: the apparent first order elimination rate constant of the drug from the central compartment estimated from an intravenous study of the same subject; r_abs: the absorption rate time course; C_δ: the concentration time profile.