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. 2016 Feb;5(1):1–14. doi: 10.3978/j.issn.2304-3881.2015.09.03

Figure 2.

Figure 2

Analysis of the effect of RAR signaling on GSIS by isolated mouse islets. (A) GSIS for islets isolated from littermate control and RARdn mice (n=5 for each strain and each glucose concentration); (B) GSIS for islets from wild type C57BL/6J mice treated with vehicle alone (control) or 1 μM all-trans-RA (n=3 for each treatment and each glucose concentration). Values are expressed as means ± SD. Statistical analyses were carried out using student’s t-test. *, P<0.05. Taken from (39). RAR, retinoic acid receptor; GSIS, glucose stimulated insulin secretion; RARdn, dominant-negative RARα.