Table 1. Clinical trials of immunoradiotherapy.
Author | Diagnosis | Sample size | Treatment | Outcome |
---|---|---|---|---|
Formenti et al. (23) | Metastatic carcinoma lung, bladder, breast, thymicca, eccrineca | 14 | GM-CSF + RT 3.5 Gy × 10# | 30% patients showed abscopal effect, five patients had metabolic response in non-irradiated area |
Chi et al. (24) | Hepatoma | 14 | 8 Gy RT + intratumoral injection of immature dendritic cells | 12 out of 14 patients had partial response |
Postow et al. (25) | Metastatic melanoma | 1 | Ipilimumab + RT 28.5 Gy in 3# | Stable minimal disease in non-irradiated part after 10 months of irradiation |
Hiniker et al. (26) | Metastatic melanoma | 1 | Ipilimumab + RT 54 Gy in 3# | Complete response in primary and metastatic site |
Slovin et al. (27) | Metastatic castration resistant prostate cancer | 50 | Ipilimumab + RT | One patient had complete response, six had stable disease and eight showed good biochemical response |
#, fractions. RT, radiotherapy.