Table S1. Principles regarding antibiotics prescription for bronchiectasis exacerbations.
Sputum bacteria | First-line medication and dose | Surrogate medication and dose | Duration |
---|---|---|---|
Streptococcus pneumoniae | Amoxicillin clavulanate 625 mg bid | Clarithromycin 500 mg bid | 14 days |
B-lactamase negative haemophilus spp | Amoxicillin clavulanate 625 mg bid | Clarithromycin 500 mg bid or levofloxacin 500 mg qd | 14 days |
B-lactamase positive haemophilus spp | Amoxicillin clavulanate 625 mg bid | Clarithromycin 500 mg bid or levofloxacin 500 mg qd | 14 days |
Moraxella catarrhalis | Amoxicillin clavulanate 625 mg bid | Levofloxacin 500 mg qd | 14 days |
Methicillin-sensitive staphylococcus aureus | Flucoxacillin 500 mg qd | Clarithromycin 500 mg bid | 14 days |
Methicillin-resistant staphylococcus aureus | Vancomycin 1.0 g bid ivdrip | Linezolid 600 mg bid ivdrip | 14 days |
Enterococcus (including Klebsiella spp) | Levofloxacin 500 mg qd | Ceftriazone 2.0 g qod ivdrip | 14 days |
Pseudomonas aeruginosa | Levofloxacin 500 mg qd | Ceftazidime 2.0 g tid ivdrip Piperacillin tazobactam 4.5 g tid ivdrip |
14 days |