Table S2. GRADE summary of findings.
| Outcomes | No. of participants (studies) follow up | Quality of the evidence (GRADE) | Relative effect (95% CI) | Anticipated absolute effects |
|
|---|---|---|---|---|---|
| Risk with control | Risk difference with experiment (95% CI) | ||||
| Objective response rate | 11,666 (24 studies) | ⊕⊕⊕⊝; moderate (due to inconsistency) | RR 1.554 (1.259–1.918) | 229 per 1,000 | 127 more per 1,000 (from 59 more to 211 more) |
| Neutropenia | 9,045 (19 studies) | ⊕⊕⊕⊝; moderate (due to risk of bias, inconsistency, publication bias, plausible confounding would change the effect) | RR 0.644 (0.35–1.185) | 70 per 1,000 | 25 fewer per 1,000 (from 45 fewer to 13 more) |
| Rash | 9,331 (19 studies) | ⊕⊕⊕⊝; moderate (due to inconsistency, publication bias, plausible confounding would change the effect) | RR 5.292 (2.89–9.691) | 15 per 1,000 | 63 more per 1,000 (from 28 more to 127 more) |
| Diarrhea | 9,111 (19 studies) | ⊕⊕⊕⊝; moderate (due to risk of bias) | RR 3.453 (2.617–4.554) | 14 per 1,000 | 35 more per 1,000 (from 23 more to 50 more) |
| Thrombocytopenia | 6,996 (16 studies) | ⊕⊕⊝⊝; low (due to risk of bias, inconsistency) | RR 1.093 (0.931–1.283) | 99 per 1,000 | 9 more per 1,000 (from 7 fewer to 28 more) |
| Anemia | 9,819 (21 studies) | ⊕⊕⊝⊝; low (due to risk of bias, inconsistency) | RR 0.811 (0.542–1.212) | 67 per 1,000 | 13 fewer per 1,000 (from 31 fewer to 14 more) |
The basis for the assumed risk (e.g., the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). GRADE working group grades of evidence: high quality, further research is very unlikely to change our confidence in the estimate of effect; moderate quality, further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate; low quality, further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate; very low quality, we are very uncertain about the estimate. CI, confidence interval; RR, risk ratio.