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. 2016 Jan 29;7:10509. doi: 10.1038/ncomms10509

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The adult myoblasts are localized in the adepithelial layer of wing discs. The myoblasts proliferate through larval development and fuse to the nascent muscle fibres in the thoracic cavity of pupae. On completion of fusion (∼36 h APF), the developing DLMs significantly increase their size, and both sarcomere units and myofibrils are assembled. Although E2F/Dp complexes occupy promoters of myogenic genes throughout development, they are needed only within a narrow temporal window during muscle growth to directly control the expression of several muscle genes. This novel role for E2F in late muscle differentiation is necessary and sufficient for adult fly viability.