Table 1.
MMR mutant mouse models in antibody diversification. Y, yes; N, no.
| MMR defect | Decreased SHM? | Decreased mutations at A:T? | Decreased CSR? | Notes | References |
|---|---|---|---|---|---|
| Msh2−/− | Y | Y | Y | [42, 43, 48, 101, 108] | |
| Msh2G674A | Y | Y | Y | inactive ATPase | [46] |
| Msh6−/− | Y | Y | Y | [44, 45, 110] | |
| Msh6T1217D | Y | Y | Y | inactive ATPase | [47] |
| Mlh1−/− | N | N | Y | [55, 101, 109] | |
| Mlh1G67R | N | N | Y | inactive ATPase | [111] |
| Pms2−/− | N | N | Y | [42, 56, 67, 101, 114] | |
| Pms2E702K | N | N | Y | inactive and unstable endonuclease | [66] |
| Msh3−/− | N | N | N | [44, 45, 110] | |
| Exo1−/− | Y | Y | Y | [50, 51] | |
| Exo1EK | N | N | N | conflicting enzymatic activity | [51][52, 53] |
| Ape1+/− | N | N | Y | [38, 98] | |
| Ape2y/m | Y | Y | Y? | conflicting CSR | [38, 39, 98] |
| PcnaK164R | Y | Y | Y? | no monoubiquitination, conflicting CSR | [60-62, 115] |
| Polh−/− | N | Y | N | [75-77, 94, 116] | |
| Polk−/− | N | N | N | backup for pol η | [93, 94, 117] |
| Ung−/− | N | N | Y | base excision repair | [33], [118] |