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. 2015 Oct 19;10(2):224–239. doi: 10.1016/j.molonc.2015.10.005

Figure 6.

Figure 6

β‐catenin KD reduces tumorigenicity/metastasis. (A) Significantly reduced tumor weight and increased body weight were observed for β‐catenin KD mice. (B) IHC for β‐catenin, MUC4, and Hematoxylin and Eosin staining for the CD18/HPAF Scr and sh‐cat tumors. Images were taken at a 20× magnification. (C) Analysis of metastases to various organs (*p = 0.03, **p = 0.02, ***p = 0.008, ****p = 0.0009). No metastases were detected in organs where the white bars are absent in the CD18 sh‐cat xenografted mice. The panel on the right shows Hematoxylin and Eosin staining for representative metastatic tumors taken from the Scr cohort. Dotted line indicates border between tumor and normal tissue. T = tumor, N = normal. Images were taken at a 20× magnification.