Table 3.

Baseline serum C-telopeptide and lipids and percent change in C-telopeptide and lipids at the end of letrozole intervention.

	Baseline	% Change	p-valuec
C-telopeptide, ng/ml
2.5 mg QD	0.53±0.46	47.67±70.86	<0.01
2.5 mg Q-MWF	0.47±0.25	37.08±57.41	<0.01
1.0 mg Q-MWF	0.38±0.17	48.73±46.23	<0.0001
0.25 mg Q-MWF	0.39±0.23	48.25±70.68	<0.01
p-valueb	0.21	0.88
Cholesterol, mg/dL
2.5 mg QD	204±43	3.68±11.66	0.11
2.5 mg Q-MWF	204±39a	3.36±13.49	0.22
1.0 mg Q-MWF	198±35	2.17±13.85	0.47
0.25 mg Q-MWF	207±28	−1.75±14.40	0.57
p-valueb	0.86	0.47
LDL, mg/dL
2.5 mg QD	120±38	4.28±15.84	0.18
2.5 mg Q-MWF	117±30	5.83±23.68	0.23
1.0 mg Q-MWF	114±31	2.28±19.37	0.59
0.25 mg Q-MWF	122±26	−1.68±18.53	0.67
p-valueb	0.82	0.58
HDL, mg/dL
2.5 mg QD	65±15	−2.12±12.24	0.39
2.5 mg Q-MWF	60±17	1.01±14.04	0.72
1.0 mg Q-MWF	64±15	−0.69±13.01	0.81
0.25 mg Q-MWF	62±16	−1.78±12.46	0.50
p-valueb	0.63	0.82
Chol/HDL
2.5 mg QD	3.30±0.86	6.13±11.44	0.01
2.5 mg Q-MWF	3.57±0.81	3.96±17.61	0.26
1.0 mg Q-MWF	3.16±0.63	3.41±11.09	0.16
0.25 mg Q-MWF	3.55±0.97	0.91±17.28	0.80
p-valueb	P=0.25	P=0.67
Triglycerides, mg/dL
2.5 mg QD	100±40	27.45±36.61	0.01
2.5 mg Q-MWF	135±62	7.92±38.56	0.28
1.0 mg Q-MWF	103±28	16.20±43.67	0.10
0.25 mg Q-MWF	122±52	7.09±28.32	0.24
p-valueb	0.04	0.17

^amean±standard deviation

^btest equality among the four groups based on one-way ANOVA

^cderived from paired t test for the % change within each group