Table 1.

Demographic and Other Baseline Characteristics

Characteristic	ACP-501 Dose (mg/kg)
	0.9 (n = 4)	3.0 (n = 4)	9.0 (n = 4)	13.5 (n = 4)	Total (N = 16)
Age, years
Mean (SD)	66.3 (2.4)	68.3 (7.9)	70.5 (6.8)	65.3 (2.9)	67.6 (5.4)
Median	67.0	68.5	72.0	66.5	67.0
Min – max	63–68	60–76	61–77	61–67	60–77
Sex, n (%)
Male	3 (75.0)	4 (100)	3 (75.0)	4 (100)	14 (87.5)
Female	1 (25.0)	0 (0.0)	1 (25.0)	0 (0.0)	2 (12.5)
Race, n (%)
Caucasian	3 (75.0)	4 (100)	2 (50.0)	3 (75.0)	12 (75.0)
Asian	1 (25.0)	0 (0.0)	1 (25.0)	1 (25.0)	3 (18.8)
Black/African American	0 (0.0)	0 (0.0)	1 (25.0)	0 (0.0)	1 (6.3)
Ethnicity, n (%)
Not Hispanic or Latino	4 (100)	4 (100)	4 (100)	4 (100)	16 (100)
Height, cm
Median	166.4	178.3	172.4	177.6	175.2
Min – max	162.0–175.9	166.5–181.9	167.5–177.4	174.5–184.8	162.0–184.8
Weight, kg
Median	81.2	93.0	82.4	79.1	83.9
Min – max	75.6–85.1	76.9–95.3	78.5–94.2	66.8–96.2	66.8–96.2
BMI, kg/m2
Median	28.8	28.8	28.8	25.4	28.1
Min – max	27.1–30.2	27.7–29.6	25.2–30.8	21.4–28.2	21.4–30.8
LCAT mass, μg/mL
Median	7.9	7.5	8.4	8.2	8.0
Min – max	6.5–11.9	6.9–8.6	6.3–13.5	6.2–8.9	6.2–13.5
HDL-C, mg/dL
Mean (SD)	40.5 (6.6)	37.8 (4.3)	35.3 (4.6)	34.8 (3.4)	37.0
Median	38.0	38.5	35.0	34.0
Min – max	36–50	32–42	30–41	32–39	32–50
LDL-C, mg/dL
Mean (SD)	72.5 (50.0)	54.3 (5.4)	71.8 (14.1)	97.0 (44.2)	73.9
Median (SD)	51.5	55	74	99
Min – max	41–146	47–60	54–85	41–149	41–149
TG, mg/dL
Mean (SD)	130.8 (60.3)	95.3 (25.5)	147.3 (71.3)	182.0(139.7)	138.9
Median	135	98	130	151
Min – max	60–194	66–119	87–242	49–378	49–378
VLDL-C, mg/dL
Mean (SD)	26.0 (12.2)	19.0 (5.3)	29.3 (14.1)	36.5 (28.1)	27.7
Median (SD)	26.5	19.5	26.0	30.0
Min – max	12–39	13–24	17–48	10–76	10–76
TC, mg/dL
Mean (SD)	138.0 (52.3)	111.0 (9.0)	138.8 (16.0)	166.3 (53.9)	138.5
Median	119	108	135	182
Min – max	101–214	104–124	124–161	92–209	92–214

Abbreviations: BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; LCAT, lecithin:cholesterol acyltransferase; SD, standard deviation