Table 1.

Aminophylline dose sliding scale. All changes were made by the pharmacist; aminophylline concentration was adjusted and study drug volume remained constant.

Theophylline Level (mcg/mL)	Dose Adjustment
<2	Increase subsequent doses by 50%
2–2.9	Increase subsequent doses by 33%
3–3.9	Increase subsequent doses by 25%
4–4.9	Increase subsequent doses by 15%
5–7 (Goal)	Target Level; No dose adjustment
7.1–8.4	Decrease subsequent doses by 10%
8.5–9.9	Decrease subsequent doses by 15%
10–12.4	Decrease subsequent doses by 25%
12.5–14.9	Decrease subsequent doses by 50%
15–19.9	Decrease subsequent doses by 67%
>19.9	Discontinue all aminophylline doses. Contact Medical Monitor.