Table 3.

Adverse events.

	Placebo (n)	Treatment (n)	Total (n)
Adverse Event
Accelerated junctional rhythm#	0	2	2
Junctional ectopic tachycardia#	2	4	6
Ventricular tachycardia	0	1	1
Ectopic atrial tachycardia	2	0	2
Sinus tachycardia	1	1	2
Unspecified tachycardia	1	1	2
Low cardiac output requiring CPR or ECMO	1	1	2
Cardiac arrhythmia leading to CPR	1	0	1
Low cardiac output with pulmonary hypertension	1	0	1
AKI*	1	1	2
Bleeding	1	0	1
Sepsis	1	0	1
Arm and jaw pain	1	0	1
Total (any event)	13^	11^	24

^#We differentiated accelerated junctional rhythm (hemodynamically insignificant, not requiring medication) from junctional ectopic tachycardia (hemodynamically significant or requiring medication)

^*AKI refers to acute kidney injury for which the managing intensivist initiated aminophylline outside of the study protocol.

^{^}p = 0.3

CPR: cardiopulmonary resuscitation; ECMO: extracorporeal membrane oxygenation