. Author manuscript; available in PMC: 2017 Mar 1.

Published in final edited form as: Curr Opin Ophthalmol. 2016 Mar;27(2):94–101. doi: 10.1097/ICU.0000000000000245

Table 1.

Summary of association (odds ratios and 95% confidence intervals) between -786 C/T NOS3^* polymorphism and high-tension glaucoma (HTG) stratified by sex

USA²²
Genotype	HTG overall	HTG (men)	HTG (women)
T/T (reference group)	1.0	1.0	1.0
C/T	1.10 (0.82 – 1.48)	1.06 (0.63 – 1.77)	1.13 (0.79 – 1.62)
C/C	1.47 (0.86 – 2.51)	1.02 (0.48 – 2.17)	1.80 (1.14 – 2.85)
# Cases/# Controls	354/1065	112/334	252/731
Brazil¹⁶
T/T (ref)	1.0	1.0	1.0
C/T	1.08 (1.00 – 3.25)	–	–
C/C	1.28 (0.48 – 3.42)	–	–
C/T or C/C	–	1.01 (0.41 – 2.49)	2.28 (1.11 – 4.76)
# Cases/# Controls	90/127	29/64	61/63
Egypt²³
T/T	1.0	1.0	1.0
C/T	1.11 (0.67 – 1.84)	1.01 (0.49 -2.10)	1.19 (0.59 – 2.42)
C/C	2.54 (1.26 – 5.13)	2.17 (0.84 – 5.63)	3.06 (1.07 – 8.74)
# Cases/# Controls	160/110	76/56	84/54

The -786 C/T NOS3 polymorphism is a function variant that results in reduced nitric oxide levels in cells because of alterations in NOS3 transcription rates.²⁴