Table 3. DTI measures of structural integrity of external capsule, hippocampus, uncinate fasciculus, cingulum, and fornix.

p-values are after multiple testing correction. Up and down arrows signify direction of change in TLE groups compared to HC.

	HC Mean ± SD	LTLE Mean ± SD	p-value (LTLE vs HC)	RTLE Mean ± SD	p-value (RTLE vs HC)
MD
L Hip	0.00098 ± 0.00006	0.00111 ± 0.00013	0.002** ↑	0.00109 ± 0.00014	0.02* ↑
R Hip	0.00097 ± 0.00007	0.00104 ± 0.00008	0.01* ↑	0.00123 ± 0.00025	0.002** ↑
L Cng	0.00078 ± 0.00004	0.00081 ± 0.00003	0.02* ↑	0.00083 ± 0.00006	0.04* ↑
R Cng	0.00079 ± 0.00004	0.00084 ± 0.00006	0.01* ↑	0.00094 ± 0.00019	0.01* ↑
FOR	0.00151 ± 0.00019	0.00171 ± 0.0003	0.02* ↑	0.00179 ± 0.00047	0.06
L Unc	0.0009 ± 0.00011	0.001 ± 0.00014	0.02* ↑	0.00092 ± 0.00007	0.37
R Unc	0.00077 ± 0.00006	0.00081 ± 0.00006	0.07	0.0008 ± 0.00005	0.21
L EC	0.00079 ± 0.00004	0.00082 ± 0.00004	0.02* ↑	0.00081 ± 0.00003	0.21
R EC	0.00074 ± 0.00002	0.00078 ± 0.00003	0.003** ↑	0.00079 ± 0.00005	0.006* ↑
FA
L Hip	0.22487 ± 0.03312	0.22323 ± 0.02797	0.45	0.21926 ± 0.05262	0.46
R Hip	0.2583 ± 0.04456	0.24938 ± 0.0329	0.28	0.23243 ± 0.03961	0.16
L Cng	0.40797 ± 0.07567	0.34327 ± 0.07501	0.02* ↓	0.36532 ± 0.134	0.21
R Cng	0.3567 ± 0.06111	0.32717 ± 0.07005	0.12	0.30906 ± 0.08959	0.13
FOR	0.40394 ± 0.0752	0.37717 ± 0.08272	0.18	0.39552 ± 0.12872	0.46
L Unc	0.27422 ± 0.08889	0.24858 ± 0.07102	0.2	0.28281 ± 0.09271	0.46
R Unc	0.39105 ± 0.08584	0.38083 ± 0.06095	0.35	0.39663 ± 0.03556	0.47
L EC	0.34768 ± 0.05949	0.31521 ± 0.046	0.07	0.34808 ± 0.03452	0.50
R EC	0.38814 ± 0.04356	0.36973 ± 0.03195	0.11	0.37242 ± 0.05033	0.30

^*Significant at 0.05 level after multiple testing correction

^**Significant at 0.01 level after multiple testing correction

Abbreviations: HC, healthy controls; LTLE, left TLE; RTLE, right TLE; L, left hemisphere; R, right hemisphere; EC, External capsule; Hip, hippocampus; Unc, uncinate; Cng, Cingulum; For, Fornix; MD, mean diffusivity; FA, fractional anisotropy; SD, standard deviation.