Table 3. DTI measures of structural integrity of external capsule, hippocampus, uncinate fasciculus, cingulum, and fornix.
HC Mean ± SD |
LTLE Mean ± SD |
p-value (LTLE vs HC) | RTLE Mean ± SD |
p-value (RTLE vs HC) | |
---|---|---|---|---|---|
MD | |||||
L Hip | 0.00098 ± 0.00006 | 0.00111 ± 0.00013 | 0.002** ↑ | 0.00109 ± 0.00014 | 0.02* ↑ |
R Hip | 0.00097 ± 0.00007 | 0.00104 ± 0.00008 | 0.01* ↑ | 0.00123 ± 0.00025 | 0.002** ↑ |
L Cng | 0.00078 ± 0.00004 | 0.00081 ± 0.00003 | 0.02* ↑ | 0.00083 ± 0.00006 | 0.04* ↑ |
R Cng | 0.00079 ± 0.00004 | 0.00084 ± 0.00006 | 0.01* ↑ | 0.00094 ± 0.00019 | 0.01* ↑ |
FOR | 0.00151 ± 0.00019 | 0.00171 ± 0.0003 | 0.02* ↑ | 0.00179 ± 0.00047 | 0.06 |
L Unc | 0.0009 ± 0.00011 | 0.001 ± 0.00014 | 0.02* ↑ | 0.00092 ± 0.00007 | 0.37 |
R Unc | 0.00077 ± 0.00006 | 0.00081 ± 0.00006 | 0.07 | 0.0008 ± 0.00005 | 0.21 |
L EC | 0.00079 ± 0.00004 | 0.00082 ± 0.00004 | 0.02* ↑ | 0.00081 ± 0.00003 | 0.21 |
R EC | 0.00074 ± 0.00002 | 0.00078 ± 0.00003 | 0.003** ↑ | 0.00079 ± 0.00005 | 0.006* ↑ |
FA | |||||
L Hip | 0.22487 ± 0.03312 | 0.22323 ± 0.02797 | 0.45 | 0.21926 ± 0.05262 | 0.46 |
R Hip | 0.2583 ± 0.04456 | 0.24938 ± 0.0329 | 0.28 | 0.23243 ± 0.03961 | 0.16 |
L Cng | 0.40797 ± 0.07567 | 0.34327 ± 0.07501 | 0.02* ↓ | 0.36532 ± 0.134 | 0.21 |
R Cng | 0.3567 ± 0.06111 | 0.32717 ± 0.07005 | 0.12 | 0.30906 ± 0.08959 | 0.13 |
FOR | 0.40394 ± 0.0752 | 0.37717 ± 0.08272 | 0.18 | 0.39552 ± 0.12872 | 0.46 |
L Unc | 0.27422 ± 0.08889 | 0.24858 ± 0.07102 | 0.2 | 0.28281 ± 0.09271 | 0.46 |
R Unc | 0.39105 ± 0.08584 | 0.38083 ± 0.06095 | 0.35 | 0.39663 ± 0.03556 | 0.47 |
L EC | 0.34768 ± 0.05949 | 0.31521 ± 0.046 | 0.07 | 0.34808 ± 0.03452 | 0.50 |
R EC | 0.38814 ± 0.04356 | 0.36973 ± 0.03195 | 0.11 | 0.37242 ± 0.05033 | 0.30 |
Significant at 0.05 level after multiple testing correction
Significant at 0.01 level after multiple testing correction
Abbreviations: HC, healthy controls; LTLE, left TLE; RTLE, right TLE; L, left hemisphere; R, right hemisphere; EC, External capsule; Hip, hippocampus; Unc, uncinate; Cng, Cingulum; For, Fornix; MD, mean diffusivity; FA, fractional anisotropy; SD, standard deviation.