Skip to main content
. Author manuscript; available in PMC: 2017 Jan 8.
Published in final edited form as: Circ Res. 2015 Oct 26;118(1):56–72. doi: 10.1161/CIRCRESAHA.115.306874

Figure 6. Human heart bioreactor.

Figure 6

A. Schematic layout of the human heart bioreactor. Arrows indicate fluid flow directions.

B. Diagram of mechanical stimulation in the human heart bioreactor. μ, strain; P, pressure; Q, volumetric flow; MV, mitral valve.

C. Representative LV-pressure vs. matrix strain curve during mechanical stimulation in the human heart bioreactor (3 cycles plotted, starting with blue and ending with red), determined by HDM analysis on the epicardial surface of the heart (inset) through biomimetic cardiac cycles.

D. Recellularization of human acellular cardiac scaffolds by intramyocardial injection between the left anterior descending artery and the left circumflex artery.

E. Recellularized human acellular cardiac scaffold inside of the bioreactor organ chamber during biomimetic culture. Black arrows indicate intramyocardial injection locations. Red arrows indicate media perfusion into main coronary arteries. Blue arrows indicate fluid flow into left ventricle balloon during mechanical stimulation.

F. Example pressure (top) and flow rate (bottom) traces in the coronary arteries (red) and left ventricle (blue) during mechanical stimulation in the human heart bioreactor.