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Rifampin concentrations in plasma and pericardium in pilot study.
A. The figure shows that at all time points the total rifampicin pericardial concentrations were dramatically lower than in the paired plasma. Derived free drug concentrations were even lower.
B. When all the concentrations at any time point were compared to the MICs, virtually all were below the MICs. Thus, no non-protein bound concentration was higher than MIC in pericardial space.
