Fig. 4.
Isoniazid concentrations in plasma and pericardial fluid (PF).
The concentration time profiles of total concentration over 24 h demonstrate matching concentration.
Clearance from pericardium was similar between plasma and pericardial fluid.
The median pericardial fluid AUC0–24 in pericardial fluid was 19.78 mg ∗ h/L compared to 18.75 mg ∗ h/L in plasma.
The median total pericardial peak concentration was 2.12 mg/L in pericardial fluid and 2.44 mg/L in plasma, virtually the same.
Isoniazid penetrated well into pericardial fluid and achieved concentrations of at least 64-fold higher than MICs.