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. 2015 Oct 3;2(11):1735–1750. doi: 10.1016/j.ebiom.2015.09.049

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This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 5 — RBC and plasma ascorbate in mice in relation to glycemia.

A. RBC ascorbate as a function of blood glucose in fed and fasted control (, ) and fed and fasted diabetic AZIP mice (, ). AZIP mice and control littermates were fed chow ad libitum until 16 h before sacrifice. Blood was withdrawn from mice that were fed or fasted 16 h and RBC ascorbate measured by HPLC. AZIP mice were tested together with littermate controls.

B. Ascorbate plasma concentrations as a function of blood glucose in fed () or fasted AZIP () mice and fed () or fasted () WT controls. Control and AZIP mice synthesize ascorbate and do not have an intake requirement for it. There was no significant difference between plasma ascorbate values in fasted AZIP mice compared to fasted WT control mice.

Inline graphic — RBC and plasma ascorbate in mice in relation to glycemia.

A. RBC ascorbate as a function of blood glucose in fed and fasted control (, ) and fed and fasted diabetic AZIP mice (, ). AZIP mice and control littermates were fed chow ad libitum until 16 h before sacrifice. Blood was withdrawn from mice that were fed or fasted 16 h and RBC ascorbate measured by HPLC. AZIP mice were tested together with littermate controls.

B. Ascorbate plasma concentrations as a function of blood glucose in fed () or fasted AZIP () mice and fed () or fasted () WT controls. Control and AZIP mice synthesize ascorbate and do not have an intake requirement for it. There was no significant difference between plasma ascorbate values in fasted AZIP mice compared to fasted WT control mice.