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A comparision of Psickle activity and sickling in red cells from HbSS and HbSC patients. Red cells were treated as described in the legend to Fig. 2. (a) K+ influx in Cl− free saline in the presence of ouabain (100 μM), bumetanide (10 μM) and CLT (5 μM). Psickle activity is calculated as the difference in K+ influx at 0 and 100 mmHg. (b) Sickling (%). Histograms represent means ± S.E.M., n = 110 for HbSC patients and n = 40 for HbSS. *** p < 0.001.
