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. 2015 Sep 18;2(11):1669–1676. doi: 10.1016/j.ebiom.2015.09.026

Fig. 7.

Fig. 7

KCC activity in red cells from HbSC and HbSS patients. Red cells were treated as described in the legends to Fig. 2. (a) Cl− dependent K+ influx in the presence of ouabain (100 μM), bumetanide (10 μM) and CLT (5 μM). Histograms represent means ± S.E.M., n = 110 for HbSC patients, and n = 40 for HbSS, *p < 0.05, ***p < 0.001. (b) Pearson correlation between KCC activity and age in red cells from HbSC patients. Correlations were calculated as r = 0.339 (p < 0.001) at 100 mmHg O2 and r = 0.614 (p < 0.001) at 0 mmHg.