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Effects of either cobicistat or ritonavir-boosted protease inhibitors on tenofovir pharmacokinetics [35–38]
| Effect on tenofovir | |||
|---|---|---|---|
| Drug | Cmax | AUC | Cmin |
| Cobicistat | 1.34 (1.34 to 1.78) | 1.23 (1.16 to 1.38) | 1.25 (1.16 to 1.36) |
| Lopinavir/r | 1.15 (1.07 to 1.22) | 1.32 (1.25 to 1.38) | 1.51 (1.37 to 1.66) |
| Atazanavir/r | 1.34 (1.20 to 1.51) | 1.37 (1.30 to 1.45) | 1.29 (1.21 to 1.36) |
| Darunavir/r | 1.24 (1.08 to 1.42) | 1.22 (1.10 to 1.35) | 1.37 (1.19 to 1.57) |
Geometric mean ratio (90% confidence intervals).
