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. 2016 Feb 4;7:24. doi: 10.3389/fimmu.2016.00024

Figure 2.

Figure 2

Dynamics of B7 ligand recognition at effector and Treg IS. (A) B7 (CD80 or CD86) ligation leads to accumulation of CD28 and associated PKC-θ at the T effector cell IS. High-affinity B7 binding by CTLA-4 on Tregs leads to accumulation of CTLA-4 and the associated PKC-η at the Treg IS, and exclusion of CD28 and PKC-θ from the IS. (B) CTLA-4 ligand binding in Tregs results in the trans-endocytosis of the B7 ligands. This reduces the amount of the B7 ligands on the surface of the APC, leading to reduced co-stimulatory signals delivered to effector T cells.