Table 1.

B7 ligand recognition in Treg synapse formation and suppressive functions.

Surface interactions	Biological significance for Tregs	Reference
CD28–B7	Motility Tonic signals necessary for survival	Lu et al. (160), Thauland et al. (163) Zhang et al. (71)
CD28–B7	Antigen recognition Motility stop signal	Apostolou et al. (176), Jordan et al. (68), Knoechel et al. (177), Walker et al. (178)
		Lu et al. (160), Thauland et al. (163)
TCR–pMHC	Synapse formation and stabilization	Onishi et al. (161)
	Activation	Schmidt et al. (179), Zhang et al. (71)
LFA-1–ICAM-1	Proliferation	Walker et al. (178), Zheng et al. (155)
	Surface accumulation of CTLA-4	Catalfamo et al. (170)
CTLA-4–B7	Synapse stabilization	Onishi et al. (161), Zanin-Zhorov et al. (151)
TCR–pMHC
LFA-1–ICAM-1	Contact suppression	Kong et al. (152), Qureshi et al. (146)