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. 2016 Feb 4;10:19. doi: 10.3389/fnins.2016.00019

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Copyright © 2016 Parsons and Huizinga.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Induction of frequency steps by localized decoupling. (A) Model diameter map (left), and its autocorrelation (right). The top of the map corresponds to the proximal (higher frequency) end. Time scales are indicated below (B). The model has the same parameters as in Figure 2A, but with coupling strength reduced by 90% (k = 0.3) at the points marked with red arrows. At the points of reduced coupling there are clear steps in frequency, corresponding to positions of dislocations in the DMap. (B) Experimental diameter map of murine small intestine (left) in the presence of 0.5 mM lidocaine to block enteric nervous system activity and its autocorrelation (right). The top of the map corresponds to the proximal end. (C) A dislocation from the model DMap in (A). (D) A dislocation from the small intestine DMap in (B).