Table 5. Cox Regression for Mortality in Patients with BOS.
| Variable | Hazard ratio (95% CI) | p value |
|---|---|---|
| Continuous variables | ||
| Pre-transplant FEV1/FVC (%) | 0.956 (0.921–0.993) | 0.020 |
| Time from HSCT to diagnosis of BOS (days) | 0.997 (0.994–0.999) | 0.009 |
| Categorical variables | ||
| Pretransplant FEV1/FVC (%) | ||
| Q4 (≥88.5) | Reference | |
| Q3 (84.5–88.5) | 4.750 (0.761–29.659) | 0.095 |
| Q2 (81.0–84.5) | 2.933 (0.533–16.143) | 0.216 |
| Q1 (<81.0) | 17.346 (2.593–116.019) | 0.003 |
| Time from HSCT to diagnosis of BOS (days) | ||
| Q4 (≥641) | Reference | |
| Q3 (466–641) | 3.991 (0.444–35.851) | 0.217 |
| Q2 (284–466) | 13.342 (1.408–126.417) | 0.024 |
| Q1 (<284) | 19.658 (2.068–186.828) | 0.010 |
BOS, bronchiolitis obliterans syndrome; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; HSCT, hematopoietic stem cell transplantation; Q, quartile.