Table 2.
Comparison of outcomes when the first quit attempt is supported by nicotine replacement therapy or varenicline versus an unassisted attempt—single and multiple quit attempt scenarios per patient over a lifetime
| Outcomes | Unassisted | NRT net | Varenicline net |
|---|---|---|---|
| Abstinence time, years | |||
| SQA | 1.52 | 1.65 | 2.89 |
| MQA | 9.92 | 3.79 | 5.84 |
| Life-years | |||
| SQA | 28.91 | 0.12 | 0.17 |
| MQA | 29.26 | 0.21 | 0.32 |
| Discounted QALYs | |||
| SQA | 14.87 | 0.04 | 0.05 |
| MQA | 14.96 | 0.07 | 0.10 |
| Discounted costs (¥) | |||
| Smoking-related disease | |||
| SQA | 3,506,972 | −283,579 | −311,073 |
| MQA | 3,340,219 | −323,986 | −391,680 |
| Direct medical, total | |||
| SQA | 3,506,972 | −240,128 | −245,814 |
| MQA | 3,340,219 | −152,192 | −176,140 |
| Indirect (lost wages) | |||
| SQA | 6,414,867 | −159,640 | −122,101 |
| MQA | 6,235,857 | −198,146 | −314,343 |
| Total costs | |||
| SQA | 9,921,839 | −399,768 | −367,915 |
| MQA | 9,576,075 | −350,338 | −490,483 |
Results for unassisted at first attempt are presented in absolute terms, while results for NRT and varenicline are presented as the difference from the unassisted SQA or MQA, respectively
¥ Japanese yen, MQA multiple quit attempts, NRT nicotine replacement therapy, QALYs quality-adjusted life-years, SQA single quit attempt