Figure 1. The model cell as a dynamical system undergoing transitions between the low (depolarized, abnormal) and high (hyperpolarized, normal) Vm states.
In this model, the transitions are associated with changes in the biological parameters which determine the electrical rectification characteristics of the voltage-gated channels. The ion channels in the cell membrane are schematically shown. We consider that the inward-rectifying channel (inward arrow) favors the hyperpolarization while the outward-rectifying channel (outward arrow) favors the depolarization.